Association between Immunohistochemical markers and MRI features in patients with glioblastoma multiforme underwent surgery

Open Access

Abstract

Background: Glioblastoma multiforme (GBM) is a common and fatal primary brain tumor. Magnetic resonance imaging (MRI) is an important tool used for diagnosing GBM. Tumor biology lights on nature and behavior of tumor which is a prime prognosticator of disease and treatment outcome and easily understood by immunohistochemical markers. If the association between Immunohistochemistry and MRI features could be established. Objectives: To investigate and find out association between immunohistochemical markers namely p53, Ki-67, MGMT and MRI features including Contrast tumor enhancement/T2 ratio, percentage of tumor necrosis/tumor volume, peritumoral edema. Materials & Methods: MRI features were taken as Contrast tumor enhancement/T2 ratio, percentage of tumor necrosis, peritumoral edema.Then associations were evaluated between p53, Ki-67, MGMT and Contrast tumor enhancement/T2 ratio, percentage of tumor necrosis/tumor volume, peritumoral edema in chi- square (χ2) test. Results: The results showed the mean age (±SD) of the population was 46.4+13.6. The age range started from minimum 13 years to maximum 70 years. Male: Female ratio was 1.75:1. Most common symptoms were headache, seizures and hemiparesis. The association between MRI features and immunomarkers in some extents were significant. The association between CTE/T2 ratio and p53 (p value 0.035), between percentage of tumor necrosis and Ki-67 (p value 0.018) and between tumor edema and MGMT (p value 0.010) were statistically significant. Conclusion: Imaging features of brain Glioblastoma such as CTE/T2, tumor necrosis percentage, degree of edema has a close association with tumor molecular pathology indicators such as the P53, Ki-67 and MGMT.